What are the primary reasons for the widespread dislike of Comic Sans MS?

Comic Sans MS is often criticized for its unprofessional appearance, perceived childishness, and overuse, particularly in contexts where it's inappropriate. It was designed to mimic the lettering in comic books, and its casual style clashes with formal or serious applications. Its ubiquity in the late 90s and early 2000s led to 'font fatigue' and a backlash against its perceived lack of sophistication.